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GSSSG (FW: 644.70), which has also exhibited a potent preventive effect on HGF nitration (Figure 1b), did not show an enhancement of c-met binding with HGF, as described earlier (Figure 1e bars 47 ), directly encouraging the notion that there is a nitration-independent mechanism centered on the unique characteristics of LASSS on HGF

However, the proteins identified as differentially expressed between non-splenectomized -thalassemia/HbE patients and healthy volunteers included a number of cytoskeletal proteins (F-actin -capping protein subunit beta, myosin light polypeptide 6, myosin regulatory light chain 12A, myosin-9, Rho GDP-dissociation inhibitor 2, transgelin-2, PDZ and LIM domain protein 1, and tropomyosin alpha-4 chain) as well as heat shock protein 70 kDa protein, integrin alpha IIb, beta-2-microglobulin, hemoglobin subunit beta, platelet factor 4 (or chemokine (C-X-C motif) and leukocyte elastase inhibitor

2, 2004, pp