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While not a complete list of warnings and adverse reactions, the most common side effects of GLP-1 drugs generally include: Nausea and/or vomiting, which most often occur after starting the medication and typically ease with time Diarrhea Abdominal discomfort, which may be accompanied by bloating or cramping

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Challengers received the Abbreviated New Drug Application (ANDA) pathway, which allows a generic to demonstrate bioequivalence to the reference listed drug without repeating the innovators clinical trials, plus a research safe harbor allowing them to conduct development activities during the patent term without infringement liability, and the 180-day exclusivity reward for challenging brand patents via P.IV certification