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Lixisenatide inhibits neuroinflammation by promoting the proteasomal degradation of thioredoxin-interacting protein (TXNIP) in ocular tissues via the PI3K/Akt signaling pathway, an effect more potent than that of insulin

Lawrance R, Degtyarev E, Griffiths P et al (2020) What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials