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According to NICE guidance (NG28), the continuation of GLP-1 receptor agonist therapy in type 2 diabetes should be assessed after six months, with treatment continued only if there is a reduction in HbA1c of at least 11 mmol/mol (1%) and, where applicable, a weight loss of at least 3% of initial body weight
demonstrated inhibition of TNF- mediated PAI-1 induction, ICAM-1 and VCAM-1 expression by liraglutide in HUVEC [96]
Trends can help distinguish a temporary fluctuation from a sustained change that deserves follow-up
These are pharmacological observations from published research
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