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There have been clinical studies done on higher oral semaglutide doses to assess its efficacy in adults without diabetes, and the results have been promising
PMCID: PMC10698219
Additionally, systematic review and meta-analysis would be helpful to address the role of GLP-1R agonists in treating DPN
SGLT-2 inhibitors SGLT-2 inhibitors were initially used to treat malaria, and later developed as hypoglycaemic agents
However, because insulin is released largely in response to rising glucose after carbohydrate intake, glucose patterns act as a useful surrogate for insulin exposure
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