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TMA can be catalyzed as TMAO by flavin mono-oxygenase 3 (FMO3), a key rate-limiting enzyme in the liver
Some patients had hypersensitivity reactions, including rash and mild swelling, but anaphylaxis was uncommon
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Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes
There's no known interaction risk between the two routes, though total copper intake should be monitored at higher combined doses
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