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Selective myostatin inhibition by apitegromab resulted in a 54.9% retention of lean mass relative to placebo, with similar total weight loss between treatment arms, indicating preservation of lean mass in the context of GLP-1 weight management

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Propensity-matching analysis using data from the SUSTAIN (subcutaneous semaglutide) and PIONEER (oral semaglutide) programs demonstrated that exposureresponse relationships for efficacy and safety were consistent between oral and subcutaneous semaglutide (Fig