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Carsten-Ren Arlt from Tosoh Bioscience, Inc

Even physiological concentrations of soluble UA have been proved to induce gene expression of macrophage-secreted inflammatory cytokines and stimulate production of reactive oxygen species in mature adipocytes

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For instance, while agents such as L-carnosine, omega-3 fatty acids, methyl-B12, and coenzyme Q10 demonstrated inconsistent or limited improvements in specific symptom domains (e.g., sleep disturbances, social cognition, gastrointestinal symptoms), others such as NAC and SFN revealed more consistent clinical benefits