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Cardiovascular safety A thorough QT study found no clinically relevant QTc prolongation, even at supratherapeutic doses
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Consequently, tubular reabsorption efficiency drops to 6070%, leading to a drastic decline in plasma free carnitine (2030 mol/L, approximately 50% of normal values)a state of loss-induced deficiency [108,109,110,111]
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Their mechanism mimics natural cardiac hormones released in response to volume overload
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