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ACS Symposium Series (2024) 1465:342
MoosaMMaartensGGunterHAllieSChughlayMSetshediMet al
These, in turn, can alter the brain and behavior or cause damage
The simulation indicated that amlodipine preferentially bound to amino acids, including proline (Pro)420, glutamic acid (Glu)424, serine (Ser)109, aspartic acid (Asp)111, arginine (Arg)458, Glu-125, alanine (Ala)510, threonine (Thr)514, Asp-517, Thr-518, lysine (Lys)114, histidine (His)145, Arg-185, leucine (Leu)115, Glu-182, and Thr-518
One important metric for adverse effects of GLP-1 RA therapies (primarily gastrointestinal discomfort that is most prevalent when initiating treatment) is C max , which is the maximum concentration of GLP-1 RA in the serum following treatment
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