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Am J Clin Nutr 8:540546
For over 60 years only three drug classes, insulin, metformin and sulfonylureas, were available for the treatment of Diabetes Mellitus (DM)
Some plans require medical documentation of diabetes or weight-related comorbidities before approving coverage
Summary SGLT2-i exert more consistent BP-lowering effects than GLP-1RA, largely due to their diuretic-like action
Future research should prioritize the development of next-generation agonists, explore combination therapies, and integrate precision medicine approaches to optimize patient outcomes
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