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10.1034/j.1600-0463.2002.100604.x APMIS

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Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)

Additionally, data indicate that women with previous neural tube defect (NTD) affected pregnancies should increase their folic acid intake to 4 mg/day PO during the period of greatest risk (1 month before and the 3 months after conception)