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A five-month treatment with PEGylated exenatide (NLY01) was found to decrease the secretion of complement 1q (C1q), IL-1, and TNF- by primary mouse microglia, thereby limiting the conversion of astrocytes to a neurotoxic phenotype

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Following the manufacturers instructions, quantitative PCR was carried out using an ABI Prism StepOnePlus Real-Time PCR System (Applied Biosystems) and PowerTrackTM SYBR Green Master Mix Applied BiosystemsTM 45,46

All NMOSD are classified (according to the leading pathophysiological mechanisms) into diseases with identifiable antibodies against aquaporin 4 AQP4-IgG (NMOSD-AQP4), NMOSD without AQP4-IgG or with unknown AQP4-IgG status and NMOSD with identified antibodies against Myelin Oligodendrocyte Glycoprotein, (NMOSD-MOG)

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