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Therapeutic Scope and the Translational Mismatch Problem Clinically, GLP-1RAs are established therapies for obesity and type 2 diabetes (T2D), with expanding indications and ongoing investigation across multiple organ systems
2gi), indicating that the pronounced weight loss induced by GLP-1MK-801 is driven by concerted and site-directed pharmacological GLP-1 receptor agonism and NMDA receptor antagonism
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