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Clinical evidence demonstrates that L-carnitine supplementation reduces fasting blood glucose ( markedly reduced fasting blood glucose and insulin resistance indices while enhancing insulin sensitivity in NAFLD mice ( Mechanistic insights into L-carnitine's effects on insulin resistance include: Inhibition of NF-B-mediated chronic inflammation: NF-B signaling promotes systemic inflammation and directly interferes with insulin signaling pathways, exacerbating IR ( Synergistic upregulation of energy metabolism and insulin signaling genes: Salic et al

It's noted that high doses of oral L-carnitine can increase TMAO levels in the bloodstream, which is associated with cardiovascular risks

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Corvallis: Oregon State University Press