The first and best-characterized mechanism is the AMPK pathway
It is understood ASADA is investigating whether some Bombers players were put on the drug, and their performance were measured against players who were not using it, with results then passed on to external parties
Mast Cell Flares (Hives, Flushing, GI Distress): By acting as a potent antioxidant, glutathione neutralizes the reactive oxygen species that provoke mast cells into degranulating, helping to stabilize the release of histamine and inflammatory cytokines
NNMT inhibition reduces consumption of nicotinamide (and of S-adenosylmethionine) by blocking the enzyme that would otherwise methylate them
For athletes and active adults specifically, the context of your sport, training calendar, and goals shapes how this is planned