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As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34

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However, the question remains as to how these drugs are used in patients with a diagnosis of cancer

A selected subset containing 614,978 projections was subsequently subjected to 3D refinement with mask on the complex and Bayesian polishing with a pixel size of 1.045

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