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Apply warm compresses: A warm cloth placed over the affected area can help reduce muscle tension and pain

Lower maintenance doses help prevent rebound while reducing drug exposure

Gradual dose escalation can significantly mitigate the frequency and severity of symptoms such as nausea and diarrhea, as it allows patients to adapt to therapy over time (Rodriguez et al., 2025)

Semaglutide can attenuate inflammation in MASLD by downregulating the IRE1-XBP1-C/EBP (inositol-requiring transmembrane kinase/endonuclease-1-X-box binding protein 1-CCAAT/enhancer binding protein ) pathway in macrophages (Hu et al., 2024), the activation of which can increase the production of PGE 2 (Chopra et al., 2019)

10.1016/S2213-8587(25)00166-4 5 BeheraL