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These changes in hippocampal circuitry are mirrored in the amygdala of APOE4 models, where early synaptic deficits further underscore the critical role of synaptic dysfunction in AD progression (Klein et al., 2010)
described in the original 1998 preclinical characterisation also carries indirect safety relevance [1]
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J Neurol 270(2):851863 Wharton S et al (2022) Gastrointestinal tolerability of once-weekly semaglutide 2.4 mg in adults with overweight or obesity, and the relationship between gastrointestinal adverse events and weight loss
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