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If taking higher doses, it is highly recommended to split the administration (e.g., one dose in the morning and one in the early afternoon) to maintain steady blood levels of the active compounds throughout the day

To be successful, manufacturers should incorporate commercial considerations into early stage clinical development decision making and be quick to revise program and portfolio strategies as new data and products emerge

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Choose a consistent time and day each week that fits your schedule

K.MorimotoR.AriokaS.MiyajiT.JugeN.et al (2006)