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Exosomes are tiny, nano-sized vesicles - about 30 to 150 nanometers in size - released by nearly all types of cells, including stem cells

Early inflammation necessary for debris clearance and infection prevention, but prolonged inflammation damages tissues

Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected

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