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Interestingly, GliT activity was not enhanced in the presence of thioredoxin from Spirulina sp., in activity assays, which indicates that GliT is specific for gliotoxin reduction and that it may operate independently of cellular thioredoxin reductase/thioredoxin systems

Baseline glycemic status significantly impacts the observed response

An oral small molecule that activates both GIP and GLP-1 receptors would effectively be "oral tirzepatide" in terms of mechanism, even if the actual molecule is chemically distinct from the tirzepatide peptide

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