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Excessive weight regain means you spend weeks after restarting just getting back to where you were
The study found that use of DPP4 inhibitors, compared with other second- or third-line glucose-lowering drugs, was associated with a 77% increase in the risk of cholangiocarcinoma (HR 1.77 [95% CI 1.04, 3.01]), although the analysis only included 27 DPP4 inhibitor-exposed events
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As such, more research is needed to compare results of the highest dose of semaglutide against the highest dose of tirzepatide
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What our study suggests is something broader: GLP-1 drugs may also quiet what I call drug noise, the relentless craving that drives addiction across substances
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