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in healthy human volunteers, the eyes open state had correlated higher FCD, ALFF, whole-brain correlation, and glucose uptake than the eyes closed state [27] and awake mice had higher FCD [59], blood flow, and oxygen metabolism [60] than mice under dexmedetomidine anesthesia

These are absolute contraindications based on animal study findings

That said, individual responses can affect how much weight is lostand it can differ with each drug

(source: lilly.com) May 2025: Illumina and Ovation.io announced plans to develop a 25,000-patient clinical multiomic dataset from GLP-1 therapy users to aid drug discovery

If its working then you will notice a reduction in your low thyroid symptoms and a reduction in your TPO antibodies