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Among genetic alterations, single-nucleotide polymorphisms (SNPs) are most implicated, with five reproducible risk loci most consistently associated with MASLD/MASH: patatin-like phospholipase domain-containing protein 3 (PNPLA3), hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), and glucokinase regulatory protein (GCKR) [47]

Modeling the potential impact of incretin-based therapies as weight-loss and diabetes treatments on population morbidity and mortality trends The RGA model Quantifying potential impacts of incretin-based therapies on mortality and morbidity outcomes is difficult, given the many uncertainties at play

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Clinical studies show equivalent efficacy and tolerability, with additional advantages of flexible dosing, lower cost, and faster access without insurance delays