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How GLP-1 Receptor Agonists Work Native GLP-1 has a short half-life of just 1-2 minutes because it is rapidly broken down in the blood by the enzyme dipeptidyl peptidase 4 (DPP-4)

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Or, to phrase that more technically, as an article published in Current Vascular Pharmacology did, nitric oxide is "continuously synthesized from the amino acid L-arginine in endothelial cells by the constitutive calcium-calmodulin-dependent enzyme nitric oxide synthase." As a vasodilator, nitric oxide relaxes the inner muscles of your blood vessels and causes the vessels to widen, thereby helping to increase blood flow and lower blood pressure