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Of clinical significance is the short-chain dicarboxylic acid, oxalic acid (oxalate)

N-Acetyl-Cysteine (NAC)is a source of the conditionally essential amino acid L-cysteine and a precursor to the tripeptide glutathione

Unlike L-arginine, it can bypass hepatic metabolism and is transported to the kidneys where it is directly converted into L-arginine [1]

Peer review Peer review information Nature Reviews Gastroenterology & Hepatology thanks A

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