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There are five known melanocortin receptors, and MT-2 primarily binds with MC-4R and MC-1R, which are involved in feeding, sexual behavior, and skin pigmentation

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This finding laid the groundwork for decades of research (noted in the table below) exploring copper-peptide signaling and its potential biomedical and cosmetic applications

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J Clin Endocrinol Metab dgae722 Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH et al (2008) Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years