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Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25

The researchers found that the drugs tended to cause weight loss for about nine months, but then weight loss plateaued

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The treatment is not FDA approved, and its use is not regulated by governing bodies, raising concerns about potential side effects and safety issues

A typical maintenance schedule might look like one shot a week, every few weeks, or even just once a month