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Ndumele, M.D., Ph.D., FAHA, chair of the American Heart Associations Council on Lifestyle and Cardiometabolic Health, who is also the director of Obesity and Cardiometabolic Research at Johns Hopkins School of Medicine

GLP-1 may affect systemic energy metabolism by regulating adipocyte development, accelerating plasma clearance of glucose and triacylglycerol-derived fatty acids, improving insulin signaling, and stimulating thermogenesis in brown adipose tissue (BAT) [40-45]

Microbiota-derived acetylcholine can promote gut motility in Drosophila melanogaster

Kim S, Heo H, Kwon SH, Park JH, Lee G, Jeon SH

A 2020 meta-analysis of 12 randomized controlled trials found modest reductions in body weight and waist circumference