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Meanwhile, the acinar cell generates its own pro-inflammatory mediators under the influence of redox-sensitive signalling cascades (87), but pancreatitis is said not to ensue when basolateral exocytosis is prevented (52)
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This agonistic mechanism does not occur when a SERM is bound to the ligand binding domain (LBD), as helix 12 dislocates and occupies the space for the coregulatory protein recognition sequence LXXLL binding [14] (Fig
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