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Despite the program ending, it rebounded in interest: Google Search Trends for various GLP-1 Drugs: The data paints an intriguing picture

Semaglutide can reduce your preference for high-fat and high-sugar foods, which are typically more palatable and rewarding, by modulating the GLP-1 receptors in the brain, which are involved in regulating reward and pleasure

Epigenomics 4 , 261268 (2012)

Secondary endpoints included the proportion of patients who achieved 10-15% reduction in weight and changes in metabolic syndrome parameters (waist circumference, HbA 1c , and blood pressure)