Finally, as this review did not include a quantitative meta-analysis, the synthesis remains qualitative and is subject to interpretation
These nuances warrant careful consideration in both clinical practice and public health policymaking
1 Although the mechanism behind bitter hops effects is still unclear, the hypothesis is that gut-exposed bitterness (the activation of the bitter taste receptors in the digestive tract rather than on the tongue) may influence appetite signals through interactions with these peptide hormones
Commonly reported effects for both peptides include injection-site reactions (redness, itching, swelling), transient flushing, headache, lightheadedness, and water retention
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