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[7] Unfortunately, data for mean growth hormone increase over 12-hour or 24-hour periods is lacking

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Adicionalmente, la sibutramina produce un aumento de la frecuencia cardiaca y la presin sangunea, que pueden ser clnicamente significativas en algunos pacientes, habindose registrado casos de arritmias, cardiopatas isqumicas y accidentes vasculares graves con su consumo

Some bodybuilders and performance athletes may gradually increase to higher dosages during short cycles, but long-term use without medical oversight is discouraged due to potential systemic effects

However, some users report difficulty falling or staying asleep, particularly during the first few weeks of treatment