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Thyroid C-Cell Tumors: In rats, Ozempic caused a dose-dependent and treatment-duration-dependent increase in thyroid C-cell tumors
The more open TMD in the static exendin-4 bound cryo-EM structure was associated with fewer stable peptide contacts (Supplemental Table 1), relative to GLP-1 and oxyntomodulin, however, the cryo-EM map was lower resolution, which precluded modelling of some of the binding site (top of TM6, ECL3 and ECL1)
Both anti-diabetic treatments function by playing key modulatory roles in the incretin system
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