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The high degree of tumor heterogeneity and adaptive cellular signaling plasticity, selection pressure, and clonal evolution substantially contribute to the resistance to molecularly targeted therapy including anti-IGF/IGF-IR agents [191]

Liver support and detoxification : The liver uses glutathione to neutralize toxins, and NAC helps keep those levels topped up

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doi: 10.1093/braincomms/fcaf385, 56 HanY.YuanM.GuoY