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Yaashikaa et al., 2024)

In ME/CFS, this protective mechanism is severely compromised

This is often due to limited dietary intake, malabsorption, medical conditions, or the use of B12-depleting medications ( Vitamin B12 deficiency is determined as follows ( Because the ability to absorb B12 from food declines with age, deficiency is more common in older adults

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Some practitioners report that lower, more frequent doses (75-100mcg nightly) produce better stress-related benefits than higher intermittent doses