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Theoretical concerns include angiogenesis-related risk in patients with current or prior cancer, and effects on nitric oxide signaling that could matter for blood pressure

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In Canada, Zepbound is approved as a long-term treatment for adults with obesity (BMI 30), or those who are overweight (BMI 27) and living with at least one weight-related health condition (including hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease)

fat mass: R 2 = 0.84) (Fig