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These also have FDA clearance

Because of this short half-life, most clinical protocols call for daily dosing or, in some cases, twice-daily dosing to maintain consistent levels in the body throughout the treatment period

This allows the supplement to be absorbed without interference from food and provides a strong start to the day

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Jeffrey Singer of the Cato Institute also proposed that making these drugs available without a prescription might reduce cost, increase access, and decrease stigma, but this change would likely take many years and receive pushback from clinicians