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They are generally exempt from FDA approval, do not have to meet GMP standards, and are regulated primarily by state pharmacy boards

In consideration of the dual roles of GLP-1RAs in hypoglycemic effects and preventing CVD among T2DM patients, we reviewed the cardiovascular effects and molecular mechanisms of GLP-1RAs in CVOTs, animal models and cultured cells, and discuss how these findings transform pharmacotherapies for T2DM, and even expand the indication of this important category of anti-diabetic drugs to CVD patients without diabetes

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This means tirzepatide could affect not only metabolism but also brain function

Who may benefit from GLP-1 therapy for weight management