In addition, there is a particular effect on endothelial integrity (indicated as +2)
Seasonal considerations Some researchers align their epitalon cycles with seasonal transitions, particularly the shift into winter when natural melatonin production changes and circadian disruption becomes more common
Conversely, patients who carry variants in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567) and mitochondrial amidoxime-reducing component 1 (MARC1, rs2642438) are more protected than the general population (48, 49)
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All findings are from short-duration preclinical models only