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There are no useful placebo controlled trials in humans for either

Low levels of this critical antioxidant can disrupt redox homeostasis, leading to increased oxidative stress and a cascade of detrimental effects on cardiovascular health

A meta-analysis of four observational studies, following a total of 7,475 older individuals for 3 to 16 years, found a weak association between an elevation in vitamin B 12 of 50 pmol/L in blood and a reduction in fracture risk (114)

[ A recent paper studied primary human monocytes which were differentiated into macrophages and subsequently exposed to different concentrations of uric acid

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