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Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation

(PubMed) Carr AC, Vissers MC

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If you dont get much of this chemical element in your diet, you could be at more risk for certain types of thyroid cancer

Further, in combination with lifestyle and diet, this drug showed greater weight loss as compared to placebo [2]