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Women with a history of copper sensitivity or who take high-dose zinc supplements (which compete with copper absorption) should track copper status if using injectable GHK-Cu for extended periods

Although the primary metabolic abnormalities leading to fat accumulation in hepatocytes remain to be elucidated, they include alterations in the pathways involving lipid uptake [dietary chylomicron remnants or adipose tissue-derived free fatty acids (FFAs)], synthesis (lipogenesis), degradation (lipolysis and lipophagy), or secretion of hepatic lipoproteins (e.g., very low-density lipoprotein [VLDL])

However, these are all speculative applications without any human trial evidence as of 2026

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