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Inconsistent use due to cost barriers often leads to yo-yo dosing, which worsens side effects when restarting
Over 40 weeks, orforglipron patients saw their A1C levels drop by 1.3% to 1.6% , depending on the dosage
Most people tolerate these well enough to continue treatment
This is why supplementation is often recommended
Older adults Age-related slowing of gastric motility (a baseline GET that may already be 10 to 20% longer than younger adults) compounds the GLP-1 effect
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