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doi: 10.1016/j.ijbiomac.2025.143989 127 ZhangHLiuXZhengYZhaXElsabaghMZhangYet al

Although this secondary analysis was not prospectively registered, both the exposure and outcomes were predefined based on those reported in the original trial, and the research question was based on a priori biological rationale

When p53 is inactivated, the accumulation of DNA damage leads to sustained senescence induction through p16 expression 29

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Menstrual status, menopause, pregnancy plans, thyroid health, insulin resistance, medications, and body-composition goals should all be considered