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Annual Review of Pathology: Mechanisms of Disease, Vol 6

Synthesis of (((ethane-1,2-diylbis(azanediyl))bis(carbonyl))bis(4,1-phenylene))diboronic acid(EBPBA) 4-Carboxyphenylboronic acid (3.65 g, 22.00 mmol), ethylenediamine dihydrochloride (1.33 g, 10.00 mmol), HATU (11.40 g, 30.00 mmol) and HOAT (4.08 g, 30.00 mmol) were dissolved in DMF (40 mL) under nitrogen atmosphere and ice bath conditions

Finally, 5 l of DTUN solution in ethanol (12 mM) was added (the final concentrations in well were as follows: 1 mM egg-PC, 1 M STY-BODIPY, 4 M inhibitor, 16 nM mFSP1, 320 nM FAD, 464 M NADPH and 0.2 mM DTUN)

Cytoprotective properties: Research has demonstrated that BPC may serve as a useful cytoprotective peptide therapy in heart disturbances, myocardial infarction, and heart failure (6)

Unfortunately, edaravone can only be used in a small subset of early-stage ALS patients (grade 1 or 2 in the Japan ALS Severity Classification, scoring at least 2 points on all 12 items of ALSFRS-R