Deep diving into GLP-1 patient forums its clear microdosing is already common practice
Glutamate levels, crucial for cognition, memory, and learning, are reduced in the model group, implying an adverse effect on brain function
The direct action of GLP-1 which can also be demonstrated in the perfused pancreas, with isolated islets and with beta cell derived cell lines involves activation of the beta cell GLP-1R which couples through the heterotrimeric G-protein Gs to activate adenylyl cyclase and increase intracellular cAMP (27, 65)
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ
Liraglutide (the active ingredient in Saxenda and Victoza) and semaglutide (the active ingredient in Ozempic) are two of the most studied options, and while they work through the same pathway, they differ in dosing, potency, side effects, and the kind of support they offer over time