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Curr Top Toxicol.1:15360

Preclinical models are often employed to assess specific risks, including the potential to induce endocarditis in susceptible hosts (160)

The agency says it can have toxic effects on the kidneys, liver, and nervous system

It is associated with increased BDNF activity, improved cerebral blood flow, and enhanced cognitive resilience

Activated JNK translocates to mitochondria and phosphorylates anti-apoptotic Bcl-2 family members (e.g., Bcl-2 phosphorylation at serine residues such as Ser70) leading to functional inactivation of Bcl-2/Bcl-xL, and promotes pro-apoptotic conformational changes and mitochondrial translocation of Bax (55, 56)