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Patients taking Zoloft for depression should follow these recommendations: Taking the 25 mg, 50 mg, and 100 mg tablets with food (mandatory) Taking 150 mg and 200 mg with or without food Swallowing the capsules without crushing them Take the liquid drug as follows: Mix it with another liquid before using it Use the dropper provided to measure the dose (dont use a teaspoon) Mix the dose with 120 ml (4 ounces) of ginger ale, lemonade, water, orange juice, or lemon-lime soda (strictly stick to any of these) Drink the mixture immediately The mixture may look cloudy, but its normal